Evidence of a Polygenic Origin of Extreme High-Density Lipoprotein Cholesterol Levels | Zendy

Mohammad Mahdi Motazacker | Zendy; Jorge Peter | Zendy; M. Treskes | Zendy; Carol C. Shoulders | Zendy; Jan Albert Kuivenhoven | Zendy; G. Kees Hovingh | Zendy

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Evidence of a Polygenic Origin of Extreme High-Density Lipoprotein Cholesterol Levels

Author(s) -

Mohammad Mahdi Motazacker,

Jorge Peter,

M. Treskes,

Carol C. Shoulders,

Jan Albert Kuivenhoven,

G. Kees Hovingh

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301505

Subject(s) - nonsynonymous substitution , genetics , biology , population , odds ratio , single nucleotide polymorphism , medicine , gene , genotype , environmental health , genome

There are several known monogenic causes of high and low high-density lipoprotein cholesterol (HDL-C) levels, but traditional sequencing studies have had limited success in identifying mutations in the majority of individuals with extreme HDL-C levels. The aim of this study was to assess the power of a targeted high-throughput sequencing strategy to elucidate the genetic basis of extreme HDL-C phenotypes.

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