Sphingomyelin Synthase 2 Activity and Liver Steatosis | Zendy

Yue Li | Zendy; Jibin Dong | Zendy; Tingbo Ding | Zendy; MingShang Kuo | Zendy; Guoqing Cao | Zendy; XianCheng Jiang | Zendy; Zhiqiang Li | Zendy

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Sphingomyelin Synthase 2 Activity and Liver Steatosis

Author(s) -

Yue Li,

Jibin Dong,

Tingbo Ding,

MingShang Kuo,

Guoqing Cao,

XianCheng Jiang,

Zhiqiang Li

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301498

Subject(s) - steatosis , sphingomyelin , atp synthase , medicine , fatty liver , endocrinology , chemistry , enzyme , biology , biochemistry , cholesterol , disease

Sphingolipid de novo biosynthesis is related to nonalcoholic fatty liver disease or hepatic steatosis. However, the mechanism is still unclear. Sphingomyelin synthase (SMS), using ceramide as one of the substrates to produce sphingomyelin, sits at the crossroads of sphingolipid biosynthesis. SMS has 2 isoforms: SMS1 and SMS2. SMS2 is the major isoform in liver.

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