mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells | Zendy

Huanchun Zhang | Zendy; W. Robert Taylor | Zendy; Giji Joseph | Zendy; Valentina Caracciolo | Zendy; Donna M. Gonzales | Zendy; Neil Sidell | Zendy; Emre Seli | Zendy; Perry J. Blackshear | Zendy; Caleb B. Kallen | Zendy

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mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells

Author(s) -

Huanchun Zhang,

W. Robert Taylor,

Giji Joseph,

Valentina Caracciolo,

Donna M. Gonzales,

Neil Sidell,

Emre Seli,

Perry J. Blackshear,

Caleb B. Kallen

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301496

Subject(s) - proinflammatory cytokine , inflammation , chemistry , microbiology and biotechnology , cytokine , macrophage , endothelial stem cell , biology , immunology , in vitro , biochemistry

We studied the expression and function of an mRNA-binding protein, zinc finger protein-36 (ZFP36), in vascular endothelial cells in vivo and in vitro. We tested the hypotheses that ZFP36 regulates inflammation in vascular endothelial cells and that it functions through direct binding to target cytokine mRNAs. We also tested whether ZFP36 inhibits nuclear factor-κB-mediated transcriptional responses in vascular endothelial cells.

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