Cocaine and Specific Cocaine Metabolites Induce von Willebrand Factor Release From Endothelial Cells in a Tissue-Specific Manner | Zendy

William E. Hobbs | Zendy; Emily E. Moore | Zendy; Rebecca Penkala | Zendy; Douglas D. Bolgiano | Zendy; José A. López | Zendy

Open Access

Cocaine and Specific Cocaine Metabolites Induce von Willebrand Factor Release From Endothelial Cells in a Tissue-Specific Manner

Author(s) -

William E. Hobbs,

Emily E. Moore,

Rebecca Penkala,

Douglas D. Bolgiano,

José A. López

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301436

Subject(s) - benzoylecgonine , von willebrand factor , platelet , umbilical vein , endothelium , pharmacology , medicine , endothelial stem cell , chemistry , endocrinology , metabolite , biochemistry , in vitro

Cocaine use is associated with arterial thrombosis, including myocardial infarction and stroke. Cocaine use results in increased plasma von Willebrand factor (VWF), accelerated atherosclerosis, and platelet-rich arterial thrombi, suggesting that cocaine activates the endothelium, promoting platelet-VWF interactions.

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