Two Isoforms of Sister-of-Mammalian Grainyhead Have Opposing Functions in Endothelial Cells and In Vivo | Zendy

Judith Haendeler | Zendy; Arne Mlynek | Zendy; Nicole Büchner | Zendy; Margarete Lukosz | Zendy; Martin Graf | Zendy; Christopher Guettler | Zendy; Sascha Jakob | Zendy; Sabrina Farrokh | Zendy; Kerstin Kunze | Zendy; Christine Goy | Zendy; Francisca Guardiola-Serrano | Zendy; Heiner Schaal | Zendy; Miriam M. CorteseKrott | Zendy; René Deenen | Zendy; Karl Köhrer | Zendy; Christoph Winkler | Zendy; Joachim Altschmied | Zendy

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Two Isoforms of Sister-of-Mammalian Grainyhead Have Opposing Functions in Endothelial Cells and In Vivo

Author(s) -

Judith Haendeler,

Arne Mlynek,

Nicole Büchner,

Margarete Lukosz,

Martin Graf,

Christopher Guettler,

Sascha Jakob,

Sabrina Farrokh,

Kerstin Kunze,

Christine Goy,

Francisca Guardiola-Serrano,

Heiner Schaal,

Miriam M. CorteseKrott,

René Deenen,

Karl Köhrer,

Christoph Winkler,

Joachim Altschmied

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301428

Subject(s) - sister , gene isoform , in vivo , biology , microbiology and biotechnology , genetics , gene , sociology , anthropology

Sister-of-Mammalian Grainyhead (SOM) is a member of the Grainyhead family of transcription factors. In humans, 3 isoforms are derived from differential first exon usage and alternative splicing and differ only in their N terminal domain. SOM2, the only variant also present in mouse, induces endothelial cell migration and protects against apoptosis. The functions of the human specific isoforms SOM1 and SOM3 have not yet been investigated. Therefore we wanted to elucidate their functions in endothelial cells.

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