Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids | Zendy

Marius R. Robciuc | Zendy; Marianna Maranghi | Zendy; Anna Lahikainen | Zendy; Daniel J. Rader | Zendy; André Bensadoun | Zendy; Katariina Öörni | Zendy; Jari Metso | Zendy; Ilenia Minicocci | Zendy; Ester Ciociola | Zendy; Fabrizio Ceci | Zendy; Anna Montali | Zendy; Marcello Arca | Zendy; Christian Ehnholm | Zendy; Matti Jauhiainen | Zendy

Open Access

Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

Author(s) -

Marius R. Robciuc,

Marianna Maranghi,

Anna Lahikainen,

Daniel J. Rader,

André Bensadoun,

Katariina Öörni,

Jari Metso,

Ilenia Minicocci,

Ester Ciociola,

Fabrizio Ceci,

Anna Montali,

Marcello Arca,

Christian Ehnholm,

Matti Jauhiainen

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301397

Subject(s) - medicine , lipoprotein lipase , endocrinology , insulin sensitivity , lipase , insulin resistance , insulin , lipoprotein , chemistry , cholesterol , biochemistry , enzyme , adipose tissue

Angiopoietin-like 3 (Angptl3) is a regulator of lipoprotein metabolism at least by inhibiting lipoprotein lipase activity. Loss-of-function mutations in ANGPTL3 cause familial combined hypolipidemia through an unknown mechanism.

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