Immunosuppressive Drug Azathioprine Reduces Aneurysm Progression Through Inhibition of Rac1 and c-Jun-Terminal-N-Kinase in Endothelial Cells | Zendy

Goran Marinković | Zendy; Stijntje Hibender | Zendy; Mark Hoogenboezem | Zendy; Amber van Broekhoven | Zendy; A F Girigorie | Zendy; Natascha Bleeker | Zendy; Anouk A.J. Hamers | Zendy; Jan Stap | Zendy; Jaap D. van Buul | Zendy; Carlie J.M. de Vries | Zendy; Vivian de Waard | Zendy

Open Access

Immunosuppressive Drug Azathioprine Reduces Aneurysm Progression Through Inhibition of Rac1 and c-Jun-Terminal-N-Kinase in Endothelial Cells

Author(s) -

Goran Marinković,

Stijntje Hibender,

Mark Hoogenboezem,

Amber van Broekhoven,

A F Girigorie,

Natascha Bleeker,

Anouk A.J. Hamers,

Jan Stap,

Jaap D. van Buul,

Carlie J.M. de Vries,

Vivian de Waard

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301394

Subject(s) - medicine , kinase , c jun , endothelium , angiotensin ii , pharmacology , inflammation , cancer research , immunology , chemistry , biochemistry , receptor , transcription factor , gene

In aortic aneurysms the arterial vessel wall is dilated because of destruction of its integrity, which may lead to lethal vessel rupture. Chronic infiltration of inflammatory cells into the vessel wall is fundamental to aneurysm pathology. We aim to limit aneurysm growth by inhibition of inflammation and reducing endothelial cell (EC) activation with immunosuppressive drug azathioprine (Aza).

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