Endothelial Von Willebrand Factor Promotes Blood–Brain Barrier Flexibility and Provides Protection From Hypoxia and Seizures in Mice | Zendy

Georgette L. Suidan | Zendy; Alexander Brill | Zendy; Simon F. De Meyer | Zendy; Jaymie R. Voorhees | Zendy; Stephen M. Cifuni | Zendy; Jessica E. Cabral | Zendy; Denisa D. Wagner | Zendy

Open Access

Endothelial Von Willebrand Factor Promotes Blood–Brain Barrier Flexibility and Provides Protection From Hypoxia and Seizures in Mice

Author(s) -

Georgette L. Suidan,

Alexander Brill,

Simon F. De Meyer,

Jaymie R. Voorhees,

Stephen M. Cifuni,

Jessica E. Cabral,

Denisa D. Wagner

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301362

Subject(s) - von willebrand factor , blood–brain barrier , status epilepticus , evans blue , von willebrand disease , tight junction , vascular permeability , central nervous system , immunology , pilocarpine , endocrinology , medicine , biology , chemistry , microbiology and biotechnology , neuroscience , epilepsy , platelet

Aberrant blood-brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel-Palade bodies from where it is released on activation into plasma and basement membrane. The role of VWF in endothelial homeostasis is unclear. The goal of this study was to assess the role of VWF in disease models associated with increased BBB permeability.

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