Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice | Zendy

Tôru Shimizu | Zendy; Yoshihiro Fukumoto | Zendy; Shin-ichi Tanaka | Zendy; Kimio Satoh | Zendy; Shohei Ikeda | Zendy; Hiroaki Shimokawa | Zendy

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Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice

Author(s) -

Tôru Shimizu,

Yoshihiro Fukumoto,

Shin-ichi Tanaka,

Kimio Satoh,

Shohei Ikeda,

Hiroaki Shimokawa

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301357

Subject(s) - rock2 , rock1 , hypoxia (environmental) , pathogenesis , rho associated protein kinase , extracellular , pulmonary hypertension , medicine , vascular smooth muscle , endocrinology , kinase , biology , protein kinase a , microbiology and biotechnology , chemistry , smooth muscle , organic chemistry , oxygen

Rho/Rho-kinase (ROCK) pathway in vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of cardiovascular diseases, including pulmonary arterial hypertension (PAH). Rho-kinase has 2 isoforms, ROCK1 and ROCK2, with different functions in different cells; ROCK1 for circulating inflammatory cells and ROCK2 for the vasculature. In the present study, we aimed to examine whether ROCK2 in VSMC is involved in the pathogenesis of PAH.

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