15-Lipoxygenase Promotes Chronic Hypoxia–Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-κB | Zendy

Jing Li | Zendy; Jingjing Rao | Zendy; Yun Liu | Zendy; Yonggang Cao | Zendy; Yueming Zhang | Zendy; Qianlong Zhang | Zendy; Daling Zhu | Zendy

Open Access

15-Lipoxygenase Promotes Chronic Hypoxia–Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-κB

Author(s) -

Jing Li,

Jingjing Rao,

Yun Liu,

Yonggang Cao,

Yueming Zhang,

Qianlong Zhang,

Daling Zhu

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301335

Subject(s) - hypoxia (environmental) , inflammation , lipoxygenase , pulmonary artery , chemistry , medicine , biochemistry , oxygen , enzyme , organic chemistry

Our laboratory has previously demonstrated that 15-lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) is involved in hypoxic pulmonary arterial hypertension. Chronic hypoxia-induced vascular inflammation has been considered as an important stage in the development of pulmonary arterial hypertension. Here, we determined the contribution of 15-HETE in the hypoxia-induced pulmonary vascular inflammation.

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