Therapeutic Reendothelialization by Induced Pluripotent Stem Cells After Vascular Injury—Brief Report | Zendy

Takashi Yamamoto | Zendy; Rei Shibata | Zendy; Masakazu Ishii | Zendy; Noriyoshi Kanemura | Zendy; Tetsutaro Kito | Zendy; Hirohiko Suzuki | Zendy; Hiroshi Miyake | Zendy; Kengo Maeda | Zendy; Tohru Tanigawa | Zendy; Noriyuki Ouchi | Zendy; Toyoaki Murohara | Zendy

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Therapeutic Reendothelialization by Induced Pluripotent Stem Cells After Vascular Injury—Brief Report

Author(s) -

Takashi Yamamoto,

Rei Shibata,

Masakazu Ishii,

Noriyoshi Kanemura,

Tetsutaro Kito,

Hirohiko Suzuki,

Hiroshi Miyake,

Kengo Maeda,

Tohru Tanigawa,

Noriyuki Ouchi,

Toyoaki Murohara

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301313

Subject(s) - induced pluripotent stem cell , human induced pluripotent stem cells , stem cell , medicine , neuroscience , biology , microbiology and biotechnology , embryonic stem cell , genetics , gene

Endothelial damage is an early requisite step for atherosclerosis after vascular injury. It has been reported that vascular wall cells can develop from induced pluripotent stem (iPS) cell-derived fetal liver kinase-1-positive (Flk-1(+)) cells. Here, we investigated the efficacies of intravenously administered iPS cell-derived Flk-1(+) cells on reendothelialization and neointimal hyperplasia in a mouse model of vascular injury.

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