Inflammatory Stress Induces Statin Resistance by Disrupting 3-Hydroxy-3-Methylglutaryl-CoA Reductase Feedback Regulation | Zendy

Yaxi Chen | Zendy; Halcyon Ku | Zendy; Lei Zhao | Zendy; David C. Wheeler | Zendy; LungChih Li | Zendy; Qing Li | Zendy; Zac Varghese | Zendy; John F. Moorhead | Zendy; Stephen H. Powis | Zendy; Ailong Huang | Zendy; Xiong Z. Ruan | Zendy

Open Access

Inflammatory Stress Induces Statin Resistance by Disrupting 3-Hydroxy-3-Methylglutaryl-CoA Reductase Feedback Regulation

Author(s) -

Yaxi Chen,

Halcyon Ku,

Lei Zhao,

David C. Wheeler,

LungChih Li,

Qing Li,

Zac Varghese,

John F. Moorhead,

Stephen H. Powis,

Ailong Huang,

Xiong Z. Ruan

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301301

Subject(s) - sterol regulatory element binding protein , hmg coa reductase , vascular smooth muscle , endocrinology , atorvastatin , medicine , sterol , cholesterol , biology , cholesteryl ester , cd36 , pharmacology , chemistry , reductase , biochemistry , lipoprotein , receptor , enzyme , smooth muscle

The risk of cardiovascular disease is increased by up to 33 to 50× in chronic inflammatory states and convention doses of statins may not provide the same cardiovascular protection as in noninflamed patients. This study investigated whether the increase in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCoA-R)-mediated cholesterol synthesis observed under inflammatory stress was resistant to the action of statins and if so, whether this was because of interference with the sterol regulatory element binding protein cleavage-activating protein pathway.

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