Endothelial Lipase Is a Critical Determinant of High-Density Lipoprotein–Stimulated Sphingosine 1-Phosphate–Dependent Signaling in Vascular Endothelium | Zendy

Satoru Tatematsu | Zendy; Sanjeev Francis | Zendy; Pradeep Natarajan | Zendy; Daniel J. Rader | Zendy; Alan Saghatelian | Zendy; Jonathan D. Brown | Zendy; Thomas Michel | Zendy; Jorge Plutzky | Zendy

Open Access

Endothelial Lipase Is a Critical Determinant of High-Density Lipoprotein–Stimulated Sphingosine 1-Phosphate–Dependent Signaling in Vascular Endothelium

Author(s) -

Satoru Tatematsu,

Sanjeev Francis,

Pradeep Natarajan,

Daniel J. Rader,

Alan Saghatelian,

Jonathan D. Brown,

Thomas Michel,

Jorge Plutzky

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301300

Subject(s) - enos , protein kinase b , angiogenesis , small interfering rna , sphingosine 1 phosphate , s1pr1 , phosphorylation , endothelial stem cell , microbiology and biotechnology , biology , sphingosine , gene knockdown , medicine , endothelium , endocrinology , signal transduction , vascular endothelial growth factor a , receptor , biochemistry , cancer research , vascular endothelial growth factor , rna , nitric oxide synthase , apoptosis , nitric oxide , in vitro , gene , vegf receptors

In addition to an extensively characterized role of high-density lipoprotein (HDL) in reverse cholesterol transport, bioactive lipids bound to HDL can also exert diverse vascular effects. Despite this, integration of HDL action in the vasculature with pathways that metabolize HDL and release bioactive lipids has been much less explored. The effects of HDL on endothelial cells are mediated in part by HDL-associated sphingosine 1-phosphate (S1P), which binds to S1P1 receptors and promotes activation of endothelial NO synthase (eNOS) and the kinase Akt. In these studies, we characterized the role of endothelial lipase (EL) in the control of endothelial signaling and biology, including those mediated by HDL-associated S1P.

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