The Myeloperoxidase Product Hypochlorous Acid Generates Irreversible High-Density Lipoprotein Receptor Inhibitors | Zendy

Veronika Binder | Zendy; Senka Ljubojević-Holzer | Zendy; Johannes Haybaeck | Zendy; Michael Holzer | Zendy; Dalia ElGamal | Zendy; Rudolf Schicho | Zendy; Burkert Pieske | Zendy; Ákos Heinemann | Zendy; Gunther Marsche | Zendy

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The Myeloperoxidase Product Hypochlorous Acid Generates Irreversible High-Density Lipoprotein Receptor Inhibitors

Author(s) -

Veronika Binder,

Senka Ljubojević-Holzer,

Johannes Haybaeck,

Michael Holzer,

Dalia ElGamal,

Rudolf Schicho,

Burkert Pieske,

Ákos Heinemann,

Gunther Marsche

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301235

Subject(s) - hypochlorous acid , myeloperoxidase , scavenger receptor , albumin , chemistry , chloramine , lipoprotein , biochemistry , receptor , pharmacology , medicine , inflammation , cholesterol , chlorine , organic chemistry

Elevated levels of advanced oxidation protein products have been described in several chronic inflammatory diseases, like chronic renal insufficiency, rheumatoid arthritis, and atherosclerosis. Recent findings revealed that advanced oxidation protein products are inhibitors of the major high-density lipoprotein receptor, scavenger receptor class B, type 1 (SR-BI). Here, we investigated which oxidation-induced structural alterations convert plasma albumin into a high-density lipoprotein-receptor inhibitor.

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