A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration | Zendy

Atsuhiko Ichimura | Zendy; Sachiko Matsumoto | Zendy; Shinobu Suzuki | Zendy; Takashi Dan | Zendy; Satoshi Yamaki | Zendy; Yayoi Sato | Zendy; Hideyasu Kiyomoto | Zendy; Naoto Ishii | Zendy; Kiyotaka Okada | Zendy; Osamu Matsuo | Zendy; Fan-Fan Hou | Zendy; Douglas E. Vaughan | Zendy; Charles van Ypersele de Strihou | Zendy; Toshio Miyata | Zendy

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A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration

Author(s) -

Atsuhiko Ichimura,

Sachiko Matsumoto,

Shinobu Suzuki,

Takashi Dan,

Satoshi Yamaki,

Yayoi Sato,

Hideyasu Kiyomoto,

Naoto Ishii,

Kiyotaka Okada,

Osamu Matsuo,

Fan-Fan Hou,

Douglas E. Vaughan,

Charles van Ypersele de Strihou,

Toshio Miyata

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301224

Subject(s) - plasminogen activator inhibitor 1 , small molecule , macrophage , activator (genetics) , chemistry , plasminogen activator , microbiology and biotechnology , cancer research , biochemistry , medicine , biology , in vitro , receptor

Macrophage (Mϕ) migration rests on the adhesion/detachment between Mϕ surface components and extracellular matrixes, and the contribution of numerous inflammatory disorders. Plasminogen activator inhibitor (PAI)-1, a serine protease inhibitor, influences Mϕ motility through an action distinct from its classical modulation of the plasmin-based fibrinolytic process. We rely here on a small molecule PAI-1 inhibitor (TM5275) to investigate the role of PAI-1 in Mϕ migration in the pathogenesis of renal injury.

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