Recombinant Lectin-Like Domain of Thrombomodulin Suppresses Vascular Inflammation by Reducing Leukocyte Recruitment via Interacting With Lewis Y on Endothelial Cells | Zendy

Wei-Ling Lin | Zendy; ChuanFa Chang | Zendy; ChungSheng Shi | Zendy; Guey-Yueh Shi | Zendy; HuaLin Wu | Zendy

Open Access

Recombinant Lectin-Like Domain of Thrombomodulin Suppresses Vascular Inflammation by Reducing Leukocyte Recruitment via Interacting With Lewis Y on Endothelial Cells

Author(s) -

Wei-Ling Lin,

ChuanFa Chang,

ChungSheng Shi,

Guey-Yueh Shi,

HuaLin Wu

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301221

Subject(s) - thrombomodulin , inflammation , lectin , recombinant dna , microbiology and biotechnology , immunology , biology , thrombin , biochemistry , gene , platelet

The N-terminal lectin-like domain (domain 1 [D1]) of thrombomodulin (TM) is known to have an anti-inflammatory function. We previously showed that recombinant TM domain 1 (rTMD1) interacts with a carbohydrate molecule, Lewis Y (Le(y)), which is found to be expressed on adhesion molecules and involved in cell adhesion. Here, we tested the effect of rTMD1/Le(y) interaction on leukocyte recruitment in inflammation.

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