Symmetrical Dimethylarginine Predicts Mortality in the General Population
Author(s) -
M. Odette Gore,
Nicole Lüneburg,
Edzard Schwedhelm,
Colby Ayers,
Maike Anderssohn,
Amit Khera,
Dorothee Atzler,
James A. de Lemos,
Peter J. Grant,
Darren K. McGuire,
Rainer H. Böger
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.113.301219
Subject(s) - medicine , hazard ratio , cardiology , confidence interval , population , asymmetric dimethylarginine , arginine , biology , biochemistry , environmental health , amino acid
Increased asymmetrical dimethylarginine (ADMA), a NO synthase inhibitor, and its congener symmetrical dimethylarginine (SDMA), predict cardiovascular and all-cause mortality in at-risk populations. Their prognostic value in the general population remains uncertain. We investigated the correlations of SDMA and ADMA with atherosclerosis and cardiovascular/all-cause mortality in the Dallas Heart Study, a multiethnic probability-based cohort aged 30 to 65 years.
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