Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction | Zendy

Andrea Ganna | Zendy; Patrik K. E. Magnusson | Zendy; Nancy L. Pedersen | Zendy; Ulf dé Fairé | Zendy; Marie Reilly | Zendy; Johan Ärnlöv | Zendy; Johan Sundström | Zendy; Anders Hamsten | Zendy; Erik Ingelsson | Zendy

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Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction

Author(s) -

Andrea Ganna,

Patrik K. E. Magnusson,

Nancy L. Pedersen,

Ulf dé Fairé,

Marie Reilly,

Johan Ärnlöv,

Johan Sundström,

Anders Hamsten,

Erik Ingelsson

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301218

Subject(s) - medicine , framingham risk score , hazard ratio , quartile , cohort , risk assessment , single nucleotide polymorphism , prospective cohort study , disease , confidence interval , genetics , genotype , biology , computer security , computer science , gene

Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use.

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