Endothelial Outgrowth Cells Shift Macrophage Phenotype and Improve Kidney Viability in Swine Renal Artery Stenosis | Zendy

Alfonso Eirin | Zendy; Xiang-Yang Zhu | Zendy; Zilun Li | Zendy; Behzad Ebrahimi | Zendy; Xin Zhang | Zendy; Hui Tang | Zendy; Michael J. Korsmo | Zendy; Alejandro Chade | Zendy; Joseph P. Grande | Zendy; Christopher J. Ward | Zendy; Robert D. Simari | Zendy; Amir Lerman | Zendy; Stephen C. Textor | Zendy; Lilach O. Lerman | Zendy

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Endothelial Outgrowth Cells Shift Macrophage Phenotype and Improve Kidney Viability in Swine Renal Artery Stenosis

Author(s) -

Alfonso Eirin,

Xiang-Yang Zhu,

Zilun Li,

Behzad Ebrahimi,

Xin Zhang,

Hui Tang,

Michael J. Korsmo,

Alejandro Chade,

Joseph P. Grande,

Christopher J. Ward,

Robert D. Simari,

Amir Lerman,

Stephen C. Textor,

Lilach O. Lerman

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301164

Subject(s) - kidney , renal artery stenosis , medicine , fibrosis , inflammation , macrophage , renal function , angiogenesis , pathology , endocrinology , renal artery , biology , in vitro , biochemistry

Endothelial outgrowth cells (EOC) decrease inflammation and improve endothelial repair. Inflammation aggravates kidney injury in renal artery stenosis (RAS), and may account for its persistence upon revascularization. We hypothesized that EOC would decrease inflammatory (M1) macrophages and improve renal recovery in RAS.

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