MicroRNAs in Stem Cell Function and Regenerative Therapy of the Heart | Zendy

Florian Seeger | Zendy; Andreas M. Zeiher | Zendy; Stefanie Dimmeler | Zendy

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MicroRNAs in Stem Cell Function and Regenerative Therapy of the Heart

Author(s) -

Florian Seeger,

Andreas M. Zeiher,

Stefanie Dimmeler

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.300138

Subject(s) - microrna , regeneration (biology) , homing (biology) , biology , stem cell , progenitor cell , endogeny , regenerative medicine , cellular differentiation , microbiology and biotechnology , bioinformatics , gene , genetics , ecology , endocrinology

MicroRNAs are small noncoding RNAs that posttranscriptionally control gene expression by targeting mRNAs. Distinct microRNAs regulate stem and progenitor cell functions, thereby modulating cell survival and homing or controlling differentiation and maturation. Experimental studies additionally show that microRNAs regulate endogenous repair and might potentially be useful to enhance the regeneration of the heart. This review summarizes the current studies that address the use of microRNAs to either improve cellular therapies or that might be targeted for enhancing endogenous tissue repair and regeneration after myocardial infarction.

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