Ezetimibe Inhibits Hepatic Niemann-Pick C1-Like 1 to Facilitate Macrophage Reverse Cholesterol Transport in Mice | Zendy

Ping Xie | Zendy; Lin Jia | Zendy; Yinyan Ma | Zendy; Juanjuan Ou | Zendy; Hongming Miao | Zendy; Nanping Wang | Zendy; Feng Guo | Zendy; Amirfarbod Yazdanyar | Zendy; Xian-Cheng Jiang | Zendy; Liqing Yu | Zendy

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Ezetimibe Inhibits Hepatic Niemann-Pick C1-Like 1 to Facilitate Macrophage Reverse Cholesterol Transport in Mice

Author(s) -

Ping Xie,

Lin Jia,

Yinyan Ma,

Juanjuan Ou,

Hongming Miao,

Nanping Wang,

Feng Guo,

Amirfarbod Yazdanyar,

Xian-Cheng Jiang,

Liqing Yu

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301187

Subject(s) - ezetimibe , reverse cholesterol transport , macrophage , chemistry , cholesterol , pharmacology , endocrinology , medicine , biochemistry , lipoprotein , in vitro

Controversies have arisen from recent mouse studies about the essential role of biliary sterol secretion in reverse cholesterol transport (RCT). The objective of this study was to examine the role of biliary cholesterol secretion in modulating macrophage RCT in Niemann-Pick C1-Like 1 (NPC1L1) liver only (L1(LivOnly)) mice, an animal model that is defective in both biliary sterol secretion and intestinal sterol absorption, and determine whether NPC1L1 inhibitor ezetimibe facilitates macrophage RCT by inhibiting hepatic NPC1L1.

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