Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors | Zendy

Jun Li | Zendy; Ngan F. Huang | Zendy; Jun Zou | Zendy; Timothy Laurent | Zendy; Jerry C. Lee | Zendy; Janet Okogbaa | Zendy; John P. Cooke | Zendy; Sheng Ding | Zendy

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Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors

Author(s) -

Jun Li,

Ngan F. Huang,

Jun Zou,

Timothy Laurent,

Jerry C. Lee,

Janet Okogbaa,

John P. Cooke,

Sheng Ding

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301167

Subject(s) - transdifferentiation , klf4 , microbiology and biotechnology , induced pluripotent stem cell , vasculogenesis , biology , endothelial stem cell , chemistry , immunology , embryonic stem cell , in vitro , stem cell , genetics , progenitor cell , gene

Transdifferentiation of fibroblasts to endothelial cells (ECs) may provide a novel therapeutic avenue for diseases, including ischemia and fibrosis. Here, we demonstrate that human fibroblasts can be transdifferentiated into functional ECs by using only 2 factors, Oct4 and Klf4, under inductive signaling conditions.

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