Beneficial Effect of Mechanical Stimulation on the Regenerative Potential of Muscle-Derived Stem Cells Is Lost by Inhibiting Vascular Endothelial Growth Factor | Zendy

Sarah Beckman | Zendy; ChienWen Chen | Zendy; Ying Tang | Zendy; Jonathan D. Proto | Zendy; Logan Mlakar | Zendy; Bing Wang | Zendy; Johnny Huard | Zendy

Open Access

Beneficial Effect of Mechanical Stimulation on the Regenerative Potential of Muscle-Derived Stem Cells Is Lost by Inhibiting Vascular Endothelial Growth Factor

Author(s) -

Sarah Beckman,

ChienWen Chen,

Ying Tang,

Jonathan D. Proto,

Logan Mlakar,

Bing Wang,

Johnny Huard

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301166

Subject(s) - stimulation , microbiology and biotechnology , regenerative medicine , growth factor , stem cell , vascular endothelial growth factor , neuroscience , biology , medicine , cancer research , vegf receptors , receptor

We previously reported that mechanical stimulation increased the effectiveness of muscle-derived stem cells (MDSCs) for tissue repair. The objective of this study was to determine the importance of vascular endothelial growth factor (VEGF) on mechanically stimulated MDSCs in a murine model of muscle regeneration.

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