Endothelial Expression of Guidance Cues in Vessel Wall Homeostasis Dysregulation Under Proatherosclerotic Conditions
Author(s) -
Janine M. van Gils,
Bhama Ramkhelawon,
Luciana Fernandes,
Merran C. Stewart,
Liang Guo,
Tara Seibert,
Gustavo Batista Menezes,
Denise Carmona Cara,
Camille Chow,
T. Bernard Kinane,
Edward A. Fisher,
Mercedes Balcells,
Jacqueline I. AlvarezLeite,
Adam LacyHulbert,
Kathryn J. Moore
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.301155
Subject(s) - netrin , chemokine , semaphorin , endothelium , proinflammatory cytokine , microbiology and biotechnology , biology , leukocyte trafficking , immunology , axon guidance , inflammation , homeostasis , neuroscience , receptor , axon , genetics
Emerging evidence suggests that neuronal guidance cues, typically expressed during development, are involved in both physiological and pathological immune responses. We hypothesized that endothelial expression of such guidance cues may regulate leukocyte trafficking into the vascular wall during atherogenesis.
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