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We demonstrated that inflammatory cells and intima-media thickening are increased in carotids exposed to low-blood flow in the SJL/J (SJL) strain compared with other mouse strains. We hypothesized that the extent of inflammation associated with intima-media thickening is a genetically regulated trait.

Identification of a Genetic Locus on Chromosome 11 That Regulates Leukocyte Infiltration in Mouse Carotid Artery