Identification of a Genetic Locus on Chromosome 11 That Regulates Leukocyte Infiltration in Mouse Carotid Artery | Zendy

Elaine M. Smolock | Zendy; Dietrich Machleder | Zendy; Vyacheslav A. Korshunov | Zendy; Bradford C. Berk | Zendy

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Identification of a Genetic Locus on Chromosome 11 That Regulates Leukocyte Infiltration in Mouse Carotid Artery

Author(s) -

Elaine M. Smolock,

Dietrich Machleder,

Vyacheslav A. Korshunov,

Bradford C. Berk

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301129

Subject(s) - locus (genetics) , congenic , quantitative trait locus , biology , pathology , infiltration (hvac) , phenotype , genetics , gene , medicine , physics , thermodynamics

We demonstrated that inflammatory cells and intima-media thickening are increased in carotids exposed to low-blood flow in the SJL/J (SJL) strain compared with other mouse strains. We hypothesized that the extent of inflammation associated with intima-media thickening is a genetically regulated trait.

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