MicroRNA-145 Restores Contractile Vascular Smooth Muscle Phenotype and Coronary Collateral Growth in the Metabolic Syndrome | Zendy

Rebecca Hutcheson | Zendy; Russell Terry | Zendy; Jennifer A. Chaplin | Zendy; Erika Smith | Zendy; Alla Musiyenko | Zendy; James C. Russell | Zendy; Thomas Lincoln | Zendy; Petra Ročić | Zendy

Open Access

MicroRNA-145 Restores Contractile Vascular Smooth Muscle Phenotype and Coronary Collateral Growth in the Metabolic Syndrome

Author(s) -

Rebecca Hutcheson,

Russell Terry,

Jennifer A. Chaplin,

Erika Smith,

Alla Musiyenko,

James C. Russell,

Thomas Lincoln,

Petra Ročić

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301116

Subject(s) - vascular smooth muscle , phenotype , medicine , endocrinology , artery , biology , contraction (grammar) , cardiology , smooth muscle , biochemistry , gene

Transient, repetitive occlusion stimulates coronary collateral growth (CCG) in normal animals. Vascular smooth muscle cells (VSMCs) switch to synthetic phenotype early in CCG, then return to contractile phenotype. CCG is impaired in the metabolic syndrome. We determined whether impaired CCG was attributable to aberrant VSMC phenotypic modulation by miR-145-mediated mechanisms, and whether restoration of physiological miR-145 levels in metabolic syndrome (JCR rat) improved CCG.

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