Relationship Among Circulating Inflammatory Proteins, Platelet Gene Expression, and Cardiovascular Risk | Zendy

David D. McManus | Zendy; Lea M. Beaulieu | Zendy; Eric Mick | Zendy; Kahraman Tanrıverdi | Zendy; Martin G. Larson | Zendy; John F. Keaney | Zendy; Emelia J. Benjamin | Zendy; Jane E. Freedman | Zendy

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Relationship Among Circulating Inflammatory Proteins, Platelet Gene Expression, and Cardiovascular Risk

Author(s) -

David D. McManus,

Lea M. Beaulieu,

Eric Mick,

Kahraman Tanrıverdi,

Martin G. Larson,

John F. Keaney,

Emelia J. Benjamin,

Jane E. Freedman

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301112

Subject(s) - framingham risk score , c reactive protein , immunology , inflammation , gene expression , fibrinogen , platelet activation , medicine , platelet , confounding , framingham heart study , disease , biology , gene , genetics

Cardiovascular disease is a complex disorder influenced by interactions of genetic variants with environmental factors. However, there is no information from large community-based studies examining the relationship of circulating cell-specific RNA to inflammatory proteins. In light of the associations among inflammatory biomarkers, obesity, platelet function, and cardiovascular disease, we sought to examine the relationships of C-reactive protein (CRP) and interleukin-6 (IL-6) to the expression of key inflammatory transcripts in platelets.

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