Plasmin Promotes Foam Cell Formation by Increasing Macrophage Catabolism of Aggregated Low-Density Lipoprotein | Zendy

Abigail S. Haka | Zendy; Inna Grosheva | Zendy; Rajesh Kumar Singh | Zendy; Frederick R. Maxfield | Zendy

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Plasmin Promotes Foam Cell Formation by Increasing Macrophage Catabolism of Aggregated Low-Density Lipoprotein

Author(s) -

Abigail S. Haka,

Inna Grosheva,

Rajesh Kumar Singh,

Frederick R. Maxfield

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301109

Subject(s) - plasmin , foam cell , chemistry , catabolism , macrophage , plasminogen activator , microbiology and biotechnology , biochemistry , ldl receptor , cell , fibrinolysis , lipoprotein , cholesterol , enzyme , biology , medicine , endocrinology , in vitro

The plasmin/plasminogen system is involved in atherosclerosis. However, the mechanisms by which it stimulates disease are not fully defined. A key event in atherogenesis is the deposition of low-density lipoprotein (LDL) on arterial walls where it is modified, aggregated, and retained. Macrophages are recruited to clear the lipoproteins, and they become foam cells. The goal of this study was to assess the role of plasmin in macrophage uptake of aggregated LDL and foam cell formation.

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