Interindividual Transcriptional Regulation of the Human biglycan Gene Involves Three Common Molecular Haplotypes | Zendy

Boris Schmitz | Zendy; Andrea Salomon | Zendy; Alois Rötrige | Zendy; Martin Ritter | Zendy; E B Ringelstein | Zendy; Jens W. Fischer | Zendy; Martin Paul | Zendy; Eva Brand | Zendy; StefanMartin Brand | Zendy

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Interindividual Transcriptional Regulation of the Human biglycan Gene Involves Three Common Molecular Haplotypes

Author(s) -

Boris Schmitz,

Andrea Salomon,

Alois Rötrige,

Martin Ritter,

E B Ringelstein,

Jens W. Fischer,

Martin Paul,

Eva Brand,

StefanMartin Brand

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301073

Subject(s) - biglycan , chromatin immunoprecipitation , promoter , biology , microbiology and biotechnology , genetics , gene , transcriptional regulation , electrophoretic mobility shift assay , transcription factor , gene expression , proteoglycan , decorin , extracellular matrix

The extracellular matrix proteoglycan biglycan (BGN) is involved in cardiovascular disease pathophysiology, as it mediates the subendothelial retention of atherogenic apolipoprotein B-containing lipoproteins, affects adaptive remodeling after myocardial infarction, and exerts proinflammatory effects in macrophages. In a cardiovascular disease-related setting of vascular endothelial cells and human monocytes, we examined the molecular mechanisms of common molecular haplotypes affecting human BGN transcriptional regulation.

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