Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis | Zendy

Katherine C. Wood | Zendy; Miriam M. CorteseKrott | Zendy; Jason C. Kovacic | Zendy; Audrey Noguchi | Zendy; Virginia B. Liu | Zendy; Xunde Wang | Zendy; Nalini Raghavachari | Zendy; Manfred Boehm | Zendy; Gregory J. Kato | Zendy; Malte Kelm | Zendy; Mark T. Gladwin | Zendy

Open Access

Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis

Author(s) -

Katherine C. Wood,

Miriam M. CorteseKrott,

Jason C. Kovacic,

Audrey Noguchi,

Virginia B. Liu,

Xunde Wang,

Nalini Raghavachari,

Manfred Boehm,

Gregory J. Kato,

Malte Kelm,

Mark T. Gladwin

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301068

Subject(s) - enos , nitric oxide , nitric oxide synthase , medicine , nitric oxide synthase type iii , endocrinology , homeostasis , endothelium , blood pressure , biology , nitrite , immunology , chemistry , ecology , nitrate

Mice genetically deficient in endothelial nitric oxide synthase (eNOS(-/-)) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. Although the current paradigm holds that this bioactivity derives specifically from the expression of eNOS in endothelium, circulating blood cells also express eNOS protein. A functional red cell eNOS that modulates vascular NO• signaling has been proposed.

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