Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular Senescence | Zendy

Shiqin Xiong | Zendy; Gloria Salazar | Zendy; Nikolay Patrushev | Zendy; Minhui Ma | Zendy; Farshad Forouzandeh | Zendy; Lula Hilenski | Zendy; R. Wayne Alexander | Zendy

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Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular Senescence

Author(s) -

Shiqin Xiong,

Gloria Salazar,

Nikolay Patrushev,

Minhui Ma,

Farshad Forouzandeh,

Lula Hilenski,

R. Wayne Alexander

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301019

Subject(s) - senescence , biology , mitochondrial biogenesis , angiotensin ii , sirtuin 1 , peroxisome proliferator activated receptor , oxidative stress , sirtuin , microbiology and biotechnology , foxo1 , downregulation and upregulation , mitochondrion , endocrinology , medicine , receptor , acetylation , signal transduction , genetics , protein kinase b , gene , blood pressure

Cellular senescence influences organismal aging and increases predisposition to age-related diseases, in particular cardiovascular disease, a leading cause of death and disability worldwide. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis and function, oxidative stress, and insulin resistance. Senescence is associated with telomere and mitochondrial dysfunction and oxidative stress, implying a potential causal role of PGC-1α in senescence pathogenesis.

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