Targeting Platelet GPIbβ Reduces Platelet Adhesion, GPIb Signaling and Thrombin Generation and Prevents Arterial Thrombosis | Zendy

Éric Maurer | Zendy; Chaojun Tang | Zendy; Mathieu Schaff | Zendy; Catherine Bourdon | Zendy; Nicolas Receveur | Zendy; Catherine Ravanat | Zendy; Anita Eckly | Zendy; Béatrice Hechler | Zendy; Christian Gachet | Zendy; François Lanza | Zendy; P Mangin | Zendy

Open Access

Targeting Platelet GPIbβ Reduces Platelet Adhesion, GPIb Signaling and Thrombin Generation and Prevents Arterial Thrombosis

Author(s) -

Éric Maurer,

Chaojun Tang,

Mathieu Schaff,

Catherine Bourdon,

Nicolas Receveur,

Catherine Ravanat,

Anita Eckly,

Béatrice Hechler,

Christian Gachet,

François Lanza,

P Mangin

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301013

Subject(s) - platelet , platelet activation , thrombin , thrombosis , platelet adhesion , thrombin generation , medicine

The glycoprotein (GP) Ib-V-IX complex regulates the adhesion, activation, and procoagulant activity of platelets. We previously reported that RAM.1, a rat monoclonal antibody directed against the extracellular domain of mouse GPIbβ, diminished adhesion of platelets and chinese hamster ovary cells transfected with the human GPIb-IX complex to von Willebrand factor under flow conditions. Here, we further evaluated the functional importance of GPIbβ by studying the impact of RAM.1 on GPIb-mediated platelet responses and in vitro and in vivo thrombus formation.

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