Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques | Zendy

Bhama Ramkhelawon | Zendy; Yuanxiao Yang | Zendy; Janine M. van Gils | Zendy; Bernd Hewing | Zendy; Katey J. Rayner | Zendy; Saj Parathath | Zendy; Liang Guo | Zendy; Scott R. Oldebeken | Zendy; Jessica L. Feig | Zendy; Edward A. Fisher | Zendy; Kathryn J. Moore | Zendy

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Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques

Author(s) -

Bhama Ramkhelawon,

Yuanxiao Yang,

Janine M. van Gils,

Bernd Hewing,

Katey J. Rayner,

Saj Parathath,

Liang Guo,

Scott R. Oldebeken,

Jessica L. Feig,

Edward A. Fisher,

Kathryn J. Moore

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301008

Subject(s) - netrin , inflammation , microbiology and biotechnology , downregulation and upregulation , macrophage , hypoxia (environmental) , receptor , immune system , cancer research , biology , chemistry , immunology , in vitro , gene , biochemistry , axon guidance , organic chemistry , axon , oxygen

Hypoxia is intimately linked to atherosclerosis and has become recognized as a primary impetus of inflammation. We recently demonstrated that the neuroimmune guidance cue netrin-1 (Ntn1) inhibits macrophage emigration from atherosclerotic plaques, thereby fostering chronic inflammation. However, the mechanisms governing netrin-1 expression in atherosclerosis are not well understood. In this study, we investigate the role of hypoxia in regulating expression of netrin-1 and its receptor uncoordinated-5-B receptor (Unc5b) in plaque macrophages and its functional consequences on these immune cells.

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