Rictor in Perivascular Adipose Tissue Controls Vascular Function by Regulating Inflammatory Molecule Expression | Zendy

Indranil Bhattacharya | Zendy; Katja Drägert | Zendy; Verena Albert | Zendy; Emmanuel Contassot | Zendy; Marlen Damjanović | Zendy; Asami Hagiwara | Zendy; Lukas Zimmerli | Zendy; Rok Humar | Zendy; Michael N. Hall | Zendy; Edouard Battegay | Zendy; Elvira Haas | Zendy

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Rictor in Perivascular Adipose Tissue Controls Vascular Function by Regulating Inflammatory Molecule Expression

Author(s) -

Indranil Bhattacharya,

Katja Drägert,

Verena Albert,

Emmanuel Contassot,

Marlen Damjanović,

Asami Hagiwara,

Lukas Zimmerli,

Rok Humar,

Michael N. Hall,

Edouard Battegay,

Elvira Haas

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.301001

Subject(s) - mtorc2 , adipose tissue , endocrinology , downregulation and upregulation , inflammation , medicine , proinflammatory cytokine , brown adipose tissue , nitric oxide synthase , tumor necrosis factor alpha , biology , adipose tissue macrophages , protein kinase b , chemistry , nitric oxide , white adipose tissue , microbiology and biotechnology , phosphorylation , mtorc1 , immunology , biochemistry , gene

Perivascular adipose tissue (PVAT) wraps blood vessels and modulates vasoreactivity by secretion of vasoactive molecules. Mammalian target of rapamycin complex 2 (mTORC2) has been shown to control inflammation and is expressed in adipose tissue. In this study, we investigated whether adipose-specific deletion of rictor and thereby inactivation of mTORC2 in PVAT may modulate vascular function by increasing inflammation in PVAT.

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