Open AccessProstaglandin D 2 -DP Signaling Promotes Endothelial Barrier Function via the cAMP/PKA/Tiam1/Rac1 Pathway
Author(s) -
Koji Kobayashi,
Yoshiki Tsubosaka,
Masatoshi Hori,
Shuh Narumiya,
Hiroshi Ozaki,
Takahisa Murata
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.300993
Subject(s) - rac1 , microbiology and biotechnology , signal transduction , function (biology) , chemistry , endocrinology , prostaglandin , guanine nucleotide exchange factor , medicine , biology
Prostaglandin D(2) (PGD(2)) is one of the prostanoids produced during inflammation. Although PGD(2) is known to decrease endothelial permeability through D prostanoid (DP) receptor stimulation, the detailed mechanism is unknown.
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