Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury | Zendy

Takashi Kohno | Zendy; Norifumi Urao | Zendy; Takashi Ashino | Zendy; Sudhahar Varadarajan | Zendy; Ronald McKinney | Zendy; Takao Hamakubo | Zendy; Hiroko Iwanari | Zendy; Masuko UshioFukai | Zendy; Tohru Fukai | Zendy

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Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury

Author(s) -

Takashi Kohno,

Norifumi Urao,

Takashi Ashino,

Sudhahar Varadarajan,

Ronald McKinney,

Takao Hamakubo,

Hiroko Iwanari,

Masuko UshioFukai,

Tohru Fukai

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300862

Subject(s) - neointima , vascular smooth muscle , microbiology and biotechnology , atp7a , rac1 , chemistry , cell migration , inflammation , downregulation and upregulation , signal transduction , medicine , endocrinology , cell , biology , biochemistry , transporter , restenosis , smooth muscle , gene , stent

Vascular smooth muscle cell (VSMC) migration is critically important for neointimal formation after vascular injury and atherosclerosis lesion formation. Copper (Cu) chelator inhibits neointimal formation, and we previously demonstrated that Cu transport protein antioxidant-1 (Atox1) is involved in Cu-induced cell growth. However, role of Atox1 in VSMC migration and neointimal formation after vascular injury is unknown.

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