Notch-Dependent Regulation of the Ischemic Vasodilatory Response—Brief Report | Zendy

Alex Chia Yu Chang | Zendy; Alexandre Patenaude | Zendy; Katherine Lu | Zendy; Megan Fuller | Zendy; Michelle Ly | Zendy; Alastair H. Kyle | Zendy; Saeid Golbidi | Zendy; Yingjin Wang | Zendy; Keith R. Walley | Zendy; Andrew I. Minchinton | Zendy; Ismail Laher | Zendy; Aly Karsan | Zendy

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Notch-Dependent Regulation of the Ischemic Vasodilatory Response—Brief Report

Author(s) -

Alex Chia Yu Chang,

Alexandre Patenaude,

Katherine Lu,

Megan Fuller,

Michelle Ly,

Alastair H. Kyle,

Saeid Golbidi,

Yingjin Wang,

Keith R. Walley,

Andrew I. Minchinton,

Ismail Laher,

Aly Karsan

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300840

Subject(s) - arteriogenesis , notch signaling pathway , vasodilation , ischemia , nitric oxide , medicine , femoral artery , microbiology and biotechnology , signal transduction , biology

We have recently described that Notch activates nitric oxide (NO) signaling in the embryonic endocardium. Both Notch signaling and NO signaling have been shown to be important during adult arteriogenesis. Notch has been shown to be required for remodeling of the collateral vessels, whereas NO is required for the initial vasodilatory response to ischemia. Whether Notch also has an impact on the vasodilatory phase of arteriogenesis after ischemia is not known. We tested the hypothesis that endothelial cell-Notch function is required for NO induction and vasodilation, in response to ischemia in the adult vasculature.

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