Mineralocorticoid Receptor Agonists Induce Mouse Aortic Aneurysm Formation and Rupture in the Presence of High Salt | Zendy

Shu Liu | Zendy; Zhongwen Xie | Zendy; Alan Daugherty | Zendy; Lisa A. Cassis | Zendy; Kevin J. Pearson | Zendy; Ming Gong | Zendy; Zhenheng Guo | Zendy

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Mineralocorticoid Receptor Agonists Induce Mouse Aortic Aneurysm Formation and Rupture in the Presence of High Salt

Author(s) -

Shu Liu,

Zhongwen Xie,

Alan Daugherty,

Lisa A. Cassis,

Kevin J. Pearson,

Ming Gong,

Zhenheng Guo

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300820

Subject(s) - mineralocorticoid receptor , aldosterone , mineralocorticoid , medicine , endocrinology , spironolactone , angiotensin ii , losartan , aortic aneurysm , angiotensin ii receptor type 1 , enalapril , receptor , aorta , cardiology , blood pressure , angiotensin converting enzyme

Elevated plasma aldosterone concentrations in patients have been linked to a spectrum of cardiovascular diseases. Mineralocorticoid receptor antagonists provide additional benefits in patients with heart failure. However, whether aldosterone and the mineralocorticoid receptor are involved in aortic aneurysm is unknown.

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