Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol | Zendy

PirkkaPekka Laurila | Zendy; Ida Surakka | Zendy; AnttiPekka Sarin | Zendy; Laxman Yetukuri | Zendy; Tuulia Hyötyläinen | Zendy; Sanni Söderlund | Zendy; Jussi Naukkarinen | Zendy; Jing Tang | Zendy; Johannes Kettunen | Zendy; Daniel B. Mirel | Zendy; Jarkko Soronen | Zendy; Terho Lehtimäki | Zendy; Aimo Ruokonen | Zendy; Christian Ehnholm | Zendy; Johan G. Eriksson | Zendy; Veikko Salomaa | Zendy; Antti Jula | Zendy; Olli T. Raitakari | Zendy; MarjoRiitta Järvelin | Zendy; Aarno Palotie | Zendy; Leena Peltonen | Zendy; Matej Orešič | Zendy; Matti Jauhiainen | Zendy; MarjaRiitta Taskinen | Zendy; Samuli Ripatti | Zendy

Open Access

Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol

Author(s) -

PirkkaPekka Laurila,

Ida Surakka,

AnttiPekka Sarin,

Laxman Yetukuri,

Tuulia Hyötyläinen,

Sanni Söderlund,

Jussi Naukkarinen,

Jing Tang,

Johannes Kettunen,

Daniel B. Mirel,

Jarkko Soronen,

Terho Lehtimäki,

Aimo Ruokonen,

Christian Ehnholm,

Johan G. Eriksson,

Veikko Salomaa,

Antti Jula,

Olli T. Raitakari,

MarjoRiitta Järvelin,

Aarno Palotie,

Leena Peltonen,

Matej Orešič,

Matti Jauhiainen,

MarjaRiitta Taskinen,

Samuli Ripatti

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300733

Subject(s) - biology , lipidomics , adipose tissue , transcriptome , single nucleotide polymorphism , population , inflammation , cholesterol , lipoprotein , genetics , endocrinology , medicine , genotype , gene , gene expression , bioinformatics , immunology , environmental health

Low high-density lipoprotein cholesterol (HDL-C) is associated with cardiometabolic pathologies. In this study, we investigate the biological pathways and individual genes behind low HDL-C by integrating results from 3 high-throughput data sources: adipose tissue transcriptomics, HDL lipidomics, and dense marker genotypes from Finnish individuals with low or high HDL-C (n=450).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research