Fenofibrate Inhibits Endothelin-1 Expression by Peroxisome Proliferator–Activated Receptor α–Dependent and Independent Mechanisms in Human Endothelial Cells | Zendy

Corine Glineur | Zendy; Barbara Gross | Zendy; Bernadette Neve | Zendy; Corinne Rommens | Zendy; Gerard T. Chew | Zendy; Françoise MartinNizard | Zendy; Fernando RodríguezPascual | Zendy; Santiago Lamas | Zendy; Gerald F. Watts | Zendy; Bart Staels | Zendy

Open Access

Fenofibrate Inhibits Endothelin-1 Expression by Peroxisome Proliferator–Activated Receptor α–Dependent and Independent Mechanisms in Human Endothelial Cells

Author(s) -

Corine Glineur,

Barbara Gross,

Bernadette Neve,

Corinne Rommens,

Gerard T. Chew,

Françoise MartinNizard,

Fernando RodríguezPascual,

Santiago Lamas,

Gerald F. Watts,

Bart Staels

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300665

Subject(s) - fenofibrate , peroxisome proliferator activated receptor , peroxisome proliferator activated receptor gamma , peroxisome proliferator activated receptor alpha , endothelin 1 , endothelin receptor , microbiology and biotechnology , chemistry , peroxisome , receptor , cancer research , medicine , endocrinology , biology , nuclear receptor , transcription factor , biochemistry , gene

Dyslipidemia contributes to endothelial dysfunction in type 2 diabetes mellitus. Fenofibrate (FF), a ligand of the peroxisome proliferator-activated receptor-α (PPARα), has beneficial effects on microvascular complications. FF may act on the endothelium by regulating vasoactive factors, including endothelin-1 (ET-1). In vitro, FF decreases ET-1 expression in human microvascular endothelial cells. We investigated the molecular mechanisms involved in the effect of FF treatment on plasma levels of ET-1 in type 2 diabetes mellitus patients.

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