Open AccessMitogen-Activated Protein Kinase 14 Is a Novel Negative Regulatory Switch for the Vascular Smooth Muscle Cell Contractile Gene Program
Author(s) -
Xiaochun Long,
Sarah L. Cowan,
Joseph M. Miano
Publication year - 2012
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.300645
Subject(s) - protein kinase a , vascular smooth muscle , microbiology and biotechnology , gene , kinase , mitogen activated protein kinase , biology , smooth muscle , endocrinology , genetics
Several studies have shown through chemical inhibitors that p38 mitogen-activated protein kinase (MAPK) promotes vascular smooth muscle cell (VSMC) differentiation. Here, we evaluate the effects of knocking down a dominant p38MAPK isoform on VSMC differentiation.
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