Ecto-5′-Nucleotidase, CD73, Is an Endothelium-Derived Hyperpolarizing Factor Synthase | Zendy

Masanori Ohta | Zendy; Kazuyoshi Toyama | Zendy; David D. Gutterman | Zendy; William B. Campbell | Zendy; Vincent Lemaître | Zendy; Ryutaro Teraoka | Zendy; Hiroto Miura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ecto-5′-Nucleotidase, CD73, Is an Endothelium-Derived Hyperpolarizing Factor Synthase

Author(s) -

Masanori Ohta,

Kazuyoshi Toyama,

David D. Gutterman,

William B. Campbell,

Vincent Lemaître,

Ryutaro Teraoka,

Hiroto Miura

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300600

Subject(s) - adenosine , vasodilation , purinergic signalling , endothelium derived hyperpolarizing factor , adenosine monophosphate , adenosine deaminase , endothelium , adenosine a1 receptor , medicine , adenine nucleotide , adenosine a3 receptor , chemistry , endocrinology , adenosine receptor , nucleotidase , biology , biochemistry , receptor , nucleotide , potassium channel , charybdotoxin , gene , agonist

Adenosine dilates human coronary arteries by activating potassium channels in an endothelial cell-independent manner. Cell surface ecto-5'-nucleotidase (CD73) rapidly dephosphorylates extracellular adenosine 5'-monophosphate to adenosine. We tested the hypothesis that coronary vasodilation to adenine nucleotides is mediated by an endothelial CD73-dependent, extracellular production of adenosine that acts as an endothelium-derived hyperpolarizing factor.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research