Hesr2 Knockout Mice Develop Aortic Valve Disease With Advancing Age | Zendy

Hiroki Kokubo | Zendy; Sachiko MiyagawaTomita | Zendy; Yasumi Nakashima | Zendy; Tsutomu Kume | Zendy; Masao Yoshizumi | Zendy; Toshio Nakanishi | Zendy; Yumiko Saga | Zendy

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Hesr2 Knockout Mice Develop Aortic Valve Disease With Advancing Age

Author(s) -

Hiroki Kokubo,

Sachiko MiyagawaTomita,

Yasumi Nakashima,

Tsutomu Kume,

Masao Yoshizumi,

Toshio Nakanishi,

Yumiko Saga

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300573

Subject(s) - regurgitation (circulation) , medicine , ventricle , aortic valve , stenosis , cardiology , fibrosis , aortic valve stenosis , knockout mouse , receptor

Acquired heart diseases, such as valve disease, are major causes of human morbidity and mortality. However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhancer of split-related (Hesr)-2 gene in the adult heart.

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