Open AccessDietary Carnosine Prevents Early Atherosclerotic Lesion Formation in Apolipoprotein E–Null Mice
Author(s) -
Oleg A. Barski,
Zhengzhi Xie,
Shahid P. Baba,
Srinivas D Sithu,
Abhinav Agarwal,
Jian Cai,
Aruni Bhatnagar,
Sanjay Srivastava
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.300572
Subject(s) - carnosine , lipid peroxidation , lesion , 4 hydroxynonenal , apolipoprotein b , chemistry , biochemistry , apolipoprotein e , lipoprotein , low density lipoprotein , medicine , pharmacology , endocrinology , cholesterol , antioxidant , pathology , disease
Atherosclerotic lesions are associated with the accumulation of reactive aldehydes derived from oxidized lipids. Although inhibition of aldehyde metabolism has been shown to exacerbate atherosclerosis and enhance the accumulation of aldehyde-modified proteins in atherosclerotic plaques, no therapeutic interventions have been devised to prevent aldehyde accumulation in atherosclerotic lesions.
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