Depolarization of Mitochondria in Endothelial Cells Promotes Cerebral Artery Vasodilation by Activation of Nitric Oxide Synthase | Zendy

Prasad V. G. Katakam | Zendy; Edina A. Wappler-Guzzetta | Zendy; Paige S. Katz | Zendy; Ibolya Rutkai | Zendy; Ádám Institóris | Zendy; Ferenc Domoki | Zendy; Tamás Gáspár | Zendy; Samuel M. Grovenburg | Zendy; James A. Snipes | Zendy; David W. Busija | Zendy

Open Access

Depolarization of Mitochondria in Endothelial Cells Promotes Cerebral Artery Vasodilation by Activation of Nitric Oxide Synthase

Author(s) -

Prasad V. G. Katakam,

Edina A. Wappler-Guzzetta,

Paige S. Katz,

Ibolya Rutkai,

Ádám Institóris,

Ferenc Domoki,

Tamás Gáspár,

Samuel M. Grovenburg,

James A. Snipes,

David W. Busija

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300560

Subject(s) - nitric oxide , vasodilation , depolarization , nitric oxide synthase , mitochondrion , endothelial nitric oxide synthase , endothelium , chemistry , medicine , cardiology , microbiology and biotechnology , biology , biochemistry , enos

Mitochondrial depolarization after ATP-sensitive potassium channel activation has been shown to induce cerebral vasodilation by the generation of calcium sparks in smooth muscle. It is unclear, however, whether mitochondrial depolarization in endothelial cells is capable of promoting vasodilation by releasing vasoactive factors. Therefore, we studied the effect of endothelial mitochondrial depolarization by mitochondrial ATP-sensitive potassium channel activators, BMS-191095 (BMS) and diazoxide, on endothelium-dependent vasodilation.

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