Overexpression of SOCS3 in T Lymphocytes Leads to Impaired Interleukin-17 Production and Severe Aortic Aneurysm Formation in Mice—Brief Report | Zendy

Mélissa Romain | Zendy; Soraya Taleb | Zendy; Marion Dalloz | Zendy; Padmapriya Ponnuswamy | Zendy; Bruno Esposito | Zendy; Nicolas Pérez | Zendy; Yu Wang | Zendy; Akihiko Yoshimura | Zendy; Alain Tedgui | Zendy; Ziad Mallat | Zendy

Open Access

Overexpression of SOCS3 in T Lymphocytes Leads to Impaired Interleukin-17 Production and Severe Aortic Aneurysm Formation in Mice—Brief Report

Author(s) -

Mélissa Romain,

Soraya Taleb,

Marion Dalloz,

Padmapriya Ponnuswamy,

Bruno Esposito,

Nicolas Pérez,

Yu Wang,

Akihiko Yoshimura,

Alain Tedgui,

Ziad Mallat

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300516

Subject(s) - socs3 , cytokine , aneurysm , stat3 , abdominal aortic aneurysm , medicine , biology , stat protein , signal transduction , immunology , cancer research , microbiology and biotechnology , surgery

Mutations of signal transducer and activator of transcription 3 (STAT3) are responsible for autosomal dominant hyperimmunoglobulin E syndrome. Recently, we reported frequent vascular abnormalities, including aneurysms in these patients, and demonstrated that STAT3 inhibition promoted aneurysm in mice. The purpose of this study was to investigate the role of cell-specific STAT3 signaling in the susceptibility to aneurysm.

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