Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis | Zendy

Maurits L. van Montfoort | Zendy; Femke Stephan | Zendy; Mandy N. Lauw | Zendy; Barbara A. Hutten | Zendy; Gerard J. van Mierlo | Zendy; Shabnam Solati | Zendy; Saskia Middeldorp | Zendy; Joost C.M. Meijers | Zendy; Sacha Zeerleder | Zendy

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Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis

Author(s) -

Maurits L. van Montfoort,

Femke Stephan,

Mandy N. Lauw,

Barbara A. Hutten,

Gerard J. van Mierlo,

Shabnam Solati,

Saskia Middeldorp,

Joost C.M. Meijers,

Sacha Zeerleder

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300498

Subject(s) - neutrophil extracellular traps , medicine , elastase , neutrophil elastase , thrombosis , immunology , venous thrombosis , confounding , odds ratio , deep vein , coagulation , gastroenterology , inflammation , enzyme , biology , biochemistry

The formation of neutrophil extracellular traps and the exposure of nucleosomes on these neutrophil extracellular traps contribute to coagulation activation and the propagation of deep vein thrombosis (DVT) in animal models. However, no data are available on the role of neutrophil extracellular traps or nucleosomes in patients with thrombosis.

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