Matrix Gla Protein Gene Polymorphism Is Associated With Increased Coronary Artery Calcification Progression | Zendy

Andrea E. CassidyBushrow | Zendy; Lawrence F. Bielak | Zendy; Albert M. Levin | Zendy; Patrick F. Sheedy | Zendy; Stephen T. Turner | Zendy; Eric Boerwinkle | Zendy; Xihong Lin | Zendy; Sharon L. R. Kardia | Zendy; Patricia A. Peyser | Zendy

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Matrix Gla Protein Gene Polymorphism Is Associated With Increased Coronary Artery Calcification Progression

Author(s) -

Andrea E. CassidyBushrow,

Lawrence F. Bielak,

Albert M. Levin,

Patrick F. Sheedy,

Stephen T. Turner,

Eric Boerwinkle,

Xihong Lin,

Sharon L. R. Kardia,

Patricia A. Peyser

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300491

Subject(s) - matrix gla protein , medicine , coronary atherosclerosis , cardiology , calcification , myocardial infarction , confidence interval , coronary artery disease , ectopic calcification

Matrix gla protein (MGP) inhibits arterial and cartilaginous calcification. A threonine to alanine (Thr83Ala) polymorphism (codon 83) in MGP is associated with myocardial infarction and femoral artery calcification. We examined the association of the MGP Thr83Ala polymorphism with quantity and progression of coronary artery calcification (CAC), a noninvasive measure of subclinical coronary atherosclerosis.

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