Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B | Zendy

Jun Mori | Zendy; Yingjie Wang | Zendy; Stuart Ellison | Zendy; Silke Heising | Zendy; Benjamin G. Neel | Zendy; Michel L. Tremblay | Zendy; Steve P. Watson | Zendy; Yotis A. Senis | Zendy

Open Access

Dominant Role of the Protein-Tyrosine Phosphatase CD148 in Regulating Platelet Activation Relative to Protein-Tyrosine Phosphatase-1B

Author(s) -

Jun Mori,

Yingjie Wang,

Stuart Ellison,

Silke Heising,

Benjamin G. Neel,

Michel L. Tremblay,

Steve P. Watson,

Yotis A. Senis

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300447

Subject(s) - protein tyrosine phosphatase , proto oncogene tyrosine protein kinase src , platelet activation , tyrosine phosphorylation , phosphorylation , platelet , tyrosine , chemistry , kinase , tyrosine kinase , phosphatase , microbiology and biotechnology , glycoprotein , receptor tyrosine kinase , biology , biochemistry , receptor , immunology

The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. In the present study, we compared the relative contributions of these PTPs in platelet activation by the major glycoprotein, glycoprotein VI, α(IIb)β(3), and C-type lectin-like receptor 2 (CLEC-2).

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