Open AccessGenetic and Pharmacologic Disruption of Interleukin-1β Signaling Inhibits Experimental Aortic Aneurysm Formation
Author(s) -
William F. Johnston,
Morgan Salmon,
Gang Su,
Guanyi Lu,
Matthew L. Stone,
Yunge Zhao,
Gary K. Owens,
Gilbert R. Upchurch,
Gorav Ailawadi
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.300432
Subject(s) - anakinra , medicine , elastin , abdominal aortic aneurysm , elastase , interleukin , perfusion , receptor antagonist , receptor , aortic aneurysm , pathogenesis , antagonist , endocrinology , cytokine , pathology , chemistry , aorta , aneurysm , surgery , biochemistry , disease , enzyme
Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis remains unknown and no specific medical therapies are available. We sought to evaluate interleukin-1β (IL-1β) and interleukin-1 receptor (IL-1R) in an experimental AAA model to identify novel therapeutic targets for AAA treatment.
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